Chemical genomics reveals inhibition of breast cancer lung metastasis by Ponatinib via c-Jun

Abstract Metastasis is the leading cause of human cancer deaths. Unfortunately, no approved drugs are available for anti-metastatic treatment. In our study, high-throughput sequencing-based high-throughput screening (HTS2) and a breast cancer lung metastasis (BCLM)-associated gene signature were com...

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Bibliographic Details
Main Authors: Wei Shao, Shasha Li, Lu Li, Kequan Lin, Xinhong Liu, Haiyan Wang, Huili Wang, Dong Wang
Format: Article
Language:English
Published: SpringerOpen 2018-04-01
Series:Protein & Cell
Subjects:
Online Access:http://link.springer.com/article/10.1007/s13238-018-0533-8