Heterosubtypic Protection Induced by a Live Attenuated Influenza Virus Vaccine Expressing Galactose-α-1,3-Galactose Epitopes in Infected Cells

Heterosubtypic Protection Induced by a Live Attenuated Influenza Virus Vaccine Expressing Galactose-α-1,3-Galactose Epitopes in Infected Cells

Influenza A viruses have multiple HA subtypes that are antigenically diverse. Classical influenza virus vaccines are subtype specific, and they cannot induce satisfactory heterosubtypic immunity against multiple influenza virus subtypes. Here, we developed a live attenuated H1N1 influenza virus vacc...

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Bibliographic Details
Main Authors: Li-Meng Yan, Sylvia P. N. Lau, Chek Meng Poh, Vera S. F. Chan, Michael C. W. Chan, Malik Peiris, Leo L. M. Poon
Format: Article
Language:English
Published: American Society for Microbiology 2020-03-01
Series:mBio
Subjects:
immunology
influenza
influenza virus vaccines
live vector vaccines
universal vaccine
Online Access:https://doi.org/10.1128/mBio.00027-20

Internet

https://doi.org/10.1128/mBio.00027-20

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