Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin
Myofibroblasts drive fibrosis in systemic sclerosis (SSc), but the cellular progenitors are unknown. Utilizing single cell RNA-sequencing, the authors show that SSc dermal myofibroblasts arise in a two-step process from SFRP2/DPP4-expressing progenitors and implicate upstream transcription factors.
Bibliographic Details
| Main Authors: |
Tracy Tabib,
Mengqi Huang,
Nina Morse,
Anna Papazoglou,
Rithika Behera,
Minxue Jia,
Melissa Bulik,
Daisy E. Monier,
Panayiotis V. Benos,
Wei Chen,
Robyn Domsic,
Robert Lafyatis |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-07-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-24607-6
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