Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin

Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin

Myofibroblasts drive fibrosis in systemic sclerosis (SSc), but the cellular progenitors are unknown. Utilizing single cell RNA-sequencing, the authors show that SSc dermal myofibroblasts arise in a two-step process from SFRP2/DPP4-expressing progenitors and implicate upstream transcription factors.

Bibliographic Details
Main Authors: Tracy Tabib, Mengqi Huang, Nina Morse, Anna Papazoglou, Rithika Behera, Minxue Jia, Melissa Bulik, Daisy E. Monier, Panayiotis V. Benos, Wei Chen, Robyn Domsic, Robert Lafyatis
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24607-6

Internet

https://doi.org/10.1038/s41467-021-24607-6

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