Candida albicans Factor H Binding Molecule Hgt1p – A Low Glucose-Induced Transmembrane Protein Is Trafficked to the Cell Wall and Impairs Phagocytosis and Killing by Human Neutrophils

Candida albicans Factor H Binding Molecule Hgt1p – A Low Glucose-Induced Transmembrane Protein Is Trafficked to the Cell Wall and Impairs Phagocytosis and Killing by Human Neutrophils

Complement is a tightly controlled arm of the innate immune system, facilitating phagocytosis and killing of invading pathogens. Factor H (FH) is the main fluid-phase inhibitor of the alternative pathway. Many pathogens can hijack FH from the host and protect themselves from complement-dependent kil...

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Bibliographic Details
Main Authors: Samyr Kenno, Cornelia Speth, Günter Rambach, Ulrike Binder, Sneha Chatterjee, Rita Caramalho, Hubertus Haas, Cornelia Lass-Flörl, Jutamas Shaughnessy, Sanjay Ram, Neil A. R. Gow, Dorothea Orth-Höller, Reinhard Würzner
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Microbiology
Subjects:
fungal infections
Candida albicans
complement system
immune evasion
factor H
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.03319/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.03319/full

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