The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis

The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of upper and lower motor neurons. Although the etiology remains unclear, disturbances in calcium homoeostasis and protein folding are essential features of neurodegeneration in this disorder. Here, w...

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Bibliographic Details
Main Authors: Vedrana eTadic, Tino ePrell, Janin eLautenschlaeger, Julian eGrosskreutz
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Amyotrophic Lateral Sclerosis
Mitochondria
Oxidative Stress
er stress
protein misfolding
TDP-43
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00147/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00147/full

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