Interactions Between Spermine-Derivatized Tentacle Porphyrins and The Human Telomeric DNA G-Quadruplex

Interactions Between Spermine-Derivatized Tentacle Porphyrins and The Human Telomeric DNA G-Quadruplex

G-rich DNA sequences have the potential to fold into non-canonical G-Quadruplex (GQ) structures implicated in aging and human diseases, notably cancers. Because stabilization of GQs at telomeres and oncogene promoters may prevent cancer, there is an interest in developing small molecules that select...

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Bibliographic Details
Main Authors: Navin C. Sabharwal, Jessica Chen, Joo Hyun (June) Lee, Chiara M. A. Gangemi, Alessandro D'Urso, Liliya A. Yatsunyk
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
G-quadruplex
tentacle porphyrins
Zn(II) porphyrin
anti-cancer therapy
end-stacking
Online Access:https://www.mdpi.com/1422-0067/19/11/3686

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https://www.mdpi.com/1422-0067/19/11/3686

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