BDNF-producing, amyloid β-specific CD4 T cells as targeted drug-delivery vehicles in Alzheimer's diseaseResearch in context

Background: The delivery of therapeutic proteins to selected sites within the central nervous system (CNS) parenchyma is a major challenge in the treatment of various neurodegenerative disorders. As brain-derived neurotrophic factor (BDNF) is reduced in the brain of people with Alzheimer's dise...

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Bibliographic Details
Main Authors: Ekaterina Eremenko, Kritika Mittal, Omer Berner, Nikita Kamenetsky, Anna Nemirovsky, Yehezqel Elyahu, Alon Monsonego
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419302531