Evaluation of gene-environment interactions for colorectal cancer susceptibility loci using case-only and case-control designs

Evaluation of gene-environment interactions for colorectal cancer susceptibility loci using case-only and case-control designs

Abstract Background Genome-wide association studies (GWAS) have identified more than 40 colorectal cancer susceptibility loci, but only a small fraction of heritability was explained. To account for missing heritability, we investigated gene-environment interactions (G × Es) between GWAS-identified...

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Bibliographic Details
Main Authors: Nan Song, Jeeyoo Lee, Sooyoung Cho, Jeongseon Kim, Jae Hwan Oh, Aesun Shin
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Cancer
Subjects:
Colorectal cancer
Gene-environment interaction
Single-nucleotide polymorphism
Case-only design
Case-control design
Online Access:https://doi.org/10.1186/s12885-019-6456-9

Internet

https://doi.org/10.1186/s12885-019-6456-9

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