Genome-Scale Architecture of Small Molecule Regulatory Networks and the Fundamental Trade-Off between Regulation and Enzymatic Activity

Genome-Scale Architecture of Small Molecule Regulatory Networks and the Fundamental Trade-Off between Regulation and Enzymatic Activity

Metabolic flux is in part regulated by endogenous small molecules that modulate the catalytic activity of an enzyme, e.g., allosteric inhibition. In contrast to transcriptional regulation of enzymes, technical limitations have hindered the production of a genome-scale atlas of small molecule-enzyme...

Full description

Bibliographic Details
Main Authors: Ed Reznik, Dimitris Christodoulou, Joshua E. Goldford, Emma Briars, Uwe Sauer, Daniel Segrè, Elad Noor
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
small molecule regulation
metabolism
trade-offs
enzyme kinetics
elasticity
regulatory network
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717311919

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717311919

Similar Items