Negative genic switch of HER-2 in the primary tumor instead of the synchronous metastatic nodal lesions after neoadjuvant chemotherapy in a patient with primary HER2-positive breast cancer

Negative genic switch of HER-2 in the primary tumor instead of the synchronous metastatic nodal lesions after neoadjuvant chemotherapy in a patient with primary HER2-positive breast cancer

Abstract Background A few retrospective studies have indicated that neoadjuvant chemotherapy (NAC) in breast cancer may change biomarker profiles of the primary tumor. Little is known about the status of HER-2 gene of the synchronous nodal metastases when that of the residual tumor undergoes negativ...

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Bibliographic Details
Main Authors: Hao-ran Chen, Yu-tuan Wu, Qiu-bo Yu, Ya-ying Yang, Yu-xian Wei, Hong-yuan Li, Kai-nan Wu, Ling-quan Kong
Format: Article
Language:English
Published: BMC 2017-10-01
Series:World Journal of Surgical Oncology
Subjects:
Breast cancer
Axillary lymph node metastases
Neoadjuvant chemotherapy
Genic switch of HER2
Online Access:http://link.springer.com/article/10.1186/s12957-017-1255-8

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http://link.springer.com/article/10.1186/s12957-017-1255-8

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