Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes

Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes

The ratio of monocytes and lymphocytes (ML ratio) in peripheral blood is associated with tuberculosis and malaria disease risk and cancer and cardiovascular disease outcomes. We studied anti-mycobacterial function and the transcriptome of monocytes in relation to the ML ratio. Mycobacterial growth i...

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Bibliographic Details
Main Authors: Vivek Naranbhai, Helen A. Fletcher, Rachel Tanner, Matthew K. O'Shea, Helen McShane, Benjamin P. Fairfax, Julian C. Knight, Adrian V.S. Hill
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:EBioMedicine
Subjects:
ML ratio
Monocyte
Transcriptome
Interferon signalling
Tuberculosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415301444

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http://www.sciencedirect.com/science/article/pii/S2352396415301444

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