Purinergic targeting enhances immunotherapy of CD73+ solid tumors with piggyBac-engineered chimeric antigen receptor natural killer cells

Purinergic targeting enhances immunotherapy of CD73+ solid tumors with piggyBac-engineered chimeric antigen receptor natural killer cells

Abstract Background The anti-tumor immunity of natural killer (NK) cells can be paralyzed by the CD73-induced generation of immunosuppressive adenosine from precursor ATP within the hypoxic microenvironment of solid tumors. In an effort to redirect purinergic immunosuppression of NK cell anti-tumor...

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Bibliographic Details
Main Authors: Jiao Wang, Kyle B. Lupo, Andrea M. Chambers, Sandro Matosevic
Format: Article
Language:English
Published: BMJ Publishing Group 2018-12-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
NK cells
Adenosine
CD73
Chimeric antigen receptor
Immunometabolism
Cancer immunotherapy
Online Access:http://link.springer.com/article/10.1186/s40425-018-0441-8

Internet

http://link.springer.com/article/10.1186/s40425-018-0441-8

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