TRPV4 Inhibition Improved Myelination and Reduced Glia Reactivity and Inflammation in a Cuprizone-Induced Mouse Model of Demyelination

TRPV4 Inhibition Improved Myelination and Reduced Glia Reactivity and Inflammation in a Cuprizone-Induced Mouse Model of Demyelination

The inhibition of demyelination and the promotion of remyelination are both considerable challenges in the therapeutic process for many central nervous system (CNS) diseases. Increasing evidence has demonstrated that neuroglial activation and neuroinflammation are responsible for myelin sheath damag...

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Bibliographic Details
Main Authors: Meiying Liu, Xuan Liu, Lei Wang, Yu Wang, Fuxing Dong, Jian Wu, Xuebin Qu, Yanan Liu, Zhian Liu, Hongbin Fan, Ruiqin Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
demyelination
inflammation
TRPV4
NF-κB
oligodendrocyte
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00392/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00392/full

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