The comprehensive native interactome of a fully functional tagged prion protein.

The comprehensive native interactome of a fully functional tagged prion protein.

The enumeration of the interaction partners of the cellular prion protein, PrP(C), may help clarifying its elusive molecular function. Here we added a carboxy proximal myc epitope tag to PrP(C). When expressed in transgenic mice, PrP(myc) carried a GPI anchor, was targeted to lipid rafts, and was gl...

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Bibliographic Details
Main Authors: Dorothea Rutishauser, Kirsten D Mertz, Rita Moos, Erich Brunner, Thomas Rülicke, Anna Maria Calella, Adriano Aguzzi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2635968?pdf=render

Internet

http://europepmc.org/articles/PMC2635968?pdf=render

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