Navigating the dynamic landscape of alpha-synuclein morphology: a review of the physiologically relevant tetrameric conformation

Navigating the dynamic landscape of alpha-synuclein morphology: a review of the physiologically relevant tetrameric conformation

N-acetylated α-synuclein (αSyn) has long been established as an intrinsically disordered protein associated with a dysfunctional role in Parkinson’s disease. In recent years, a physiologically relevant, higher order conformation has been identified as a helical tetramer that is tailored by buried hy...

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Bibliographic Details
Main Authors: Heather R Lucas, Ricardo D Fernández
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Neural Regeneration Research
Subjects:
alpha-synuclein; amyloid fibrils; intrinsically disordered protein; multimer; N-acetylation; oligomer; Parkinson’s disease; protein folding; protein structure; tetramer
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=3;spage=407;epage=415;aulast=Lucas

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=3;spage=407;epage=415;aulast=Lucas

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