The Potential Role of Regulatory Genes (DNMT3A, HDAC5, and HDAC9) in Antipsychotic Treatment Response in South African Schizophrenia Patients

The Potential Role of Regulatory Genes (DNMT3A, HDAC5, and HDAC9) in Antipsychotic Treatment Response in South African Schizophrenia Patients

Despite advances in pharmacogenetics, the majority of heritability for treatment response cannot be explained by common variation, suggesting that factors such as epigenetics may play a key role. Regulatory genes, such as those involved in DNA methylation and transcriptional repression, are therefor...

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Bibliographic Details
Main Authors: Kevin Sean O’Connell, Nathaniel Wade McGregor, Robin Emsley, Soraya Seedat, Louise Warnich
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Genetics
Subjects:
schizophrenia
epigenetics
neuropsychiatric genetics
gene expression
treatment response
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00641/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00641/full

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