Genome-wide binding of MBD2 reveals strong preference for highly methylated loci.

Genome-wide binding of MBD2 reveals strong preference for highly methylated loci.

MBD2 is a subunit of the NuRD complex that is postulated to mediate gene repression via recruitment of the complex to methylated DNA. In this study we adopted an MBD2 tagging-approach to study its genome wide binding characteristics. We show that in vivo MBD2 is mainly recruited to CpG island promot...

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Bibliographic Details
Main Authors: Roberta Menafra, Arie B Brinkman, Filomena Matarese, Gianluigi Franci, Stefanie J J Bartels, Luan Nguyen, Takashi Shimbo, Paul A Wade, Nina C Hubner, Hendrik G Stunnenberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4057170?pdf=render

Internet

http://europepmc.org/articles/PMC4057170?pdf=render

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