Mechanisms of glucosamine-induced suppression of the hepatic assembly and secretion of apolipoprotein B-100-containing lipoproteins

Mechanisms of glucosamine-induced suppression of the hepatic assembly and secretion of apolipoprotein B-100-containing lipoproteins

Glucosamine-induced endoplasmic reticulum (ER) stress was recently shown to specifically reduce apolipoprotein B-100 (apoB-100) secretion by enhancing the proteasomal degradation of apoB-100. Here, we examined the mechanisms linking glucosamine-induced ER stress and apoB-lipoprotein biogenesis. Tryp...

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Bibliographic Details
Main Authors: Wei Qiu, Rita Kohen Avramoglu, Angela C. Rutledge, Julie Tsai, Khosrow Adeli
Format: Article
Language:English
Published: Elsevier 2006-08-01
Series:Journal of Lipid Research
Subjects:
very low density lipoprotein
hepatocytes
apolipoprotein B degredation
proteasome
glycosylation
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520331606

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http://www.sciencedirect.com/science/article/pii/S0022227520331606

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