Reduction in mitochondrial oxidative stress mediates hypoxia-induced resistance to cisplatin in human transitional cell carcinoma cells

Reduction in mitochondrial oxidative stress mediates hypoxia-induced resistance to cisplatin in human transitional cell carcinoma cells

Tumor hypoxia is known to promote the acquisition of more aggressive phenotypes in human transitional cell carcinoma (TCC), including drug resistance. Accumulating evidence suggests that mitochondria play a central role in the chemoresistance of TCC. However, the role of mitochondria in the hypoxia-...

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Bibliographic Details
Main Authors: Myung-Chul Kim, Sung-Hyun Hwang, Yeseul Yang, Na-Yon Kim, Yongbaek Kim
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Hypoxia
Drug resistance
Mitochondria
mtDNA
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S147655862100035X

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http://www.sciencedirect.com/science/article/pii/S147655862100035X

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