Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer

Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer

The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can inhibit growth in CARM1 expressing ovarian can...

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Bibliographic Details
Main Authors: Jianhuang Lin, Heng Liu, Takeshi Fukumoto, Joseph Zundell, Qingqing Yan, Chih-Hang Anthony Tang, Shuai Wu, Wei Zhou, Dajiang Guo, Sergey Karakashev, Chih-Chi Andrew Hu, Kavitha Sarma, Andrew V. Kossenkov, Rugang Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25684-3

Internet

https://doi.org/10.1038/s41467-021-25684-3

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