ALS-Associated E478G Mutation in Human OPTN (Optineurin) Promotes Inflammation and Induces Neuronal Cell Death

ALS-Associated E478G Mutation in Human OPTN (Optineurin) Promotes Inflammation and Induces Neuronal Cell Death

Amyotrophic Lateral Sclerosis (ALS) is a group of neurodegenerative disorders that featured with the death of motor neurons, which leads to loss of voluntary control on muscles. The etiologies vary among different subtypes of ALS, and no effective management or medication could be provided to the pa...

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Bibliographic Details
Main Authors: Zhengzhao Liu, Hongming Li, Chungu Hong, Menglu Chen, Tao Yue, Chunyuan Chen, Zhenxing Wang, Qing You, Chuanyin Li, Qinjie Weng, Hui Xie, Ronggui Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
optineurin
ALS
inflammation
cell death
cytokines
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02647/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02647/full

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