Therapeutic potential of growth differentiation factors in the treatment of degenerative disc diseases

Therapeutic potential of growth differentiation factors in the treatment of degenerative disc diseases

Intervertebral disc (IVD) degeneration is a major contributing factor to chronic low back pain and disability, leading to imbalance between anabolic and catabolic processes, altered extracellular matrix composition, loss of tissue hydration, inflammation, and impaired mechanical functionality. Curre...

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Bibliographic Details
Main Authors: Tom Hodgkinson, Bojiang Shen, Ashish Diwan, Judith A. Hoyland, Stephen M. Richardson
Format: Article
Language:English
Published: Wiley 2019-03-01
Series:JOR Spine
Subjects:
annulus fibrosus
bone morphogenetic protein
cartilage derived morphogenetic protein (CDMP)
growth differentiation factor (GDF)
intervertebral disc degeneration, nucleus pulposus
mesenchymal stem cell
Online Access:https://doi.org/10.1002/jsp2.1045

Internet

https://doi.org/10.1002/jsp2.1045

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