Combining Vγ9Vδ2 T Cells with a Lipophilic Bisphosphonate Efficiently Kills Activated Hepatic Stellate Cells

Combining Vγ9Vδ2 T Cells with a Lipophilic Bisphosphonate Efficiently Kills Activated Hepatic Stellate Cells

Activated hepatic stellate cells (aHSCs) are now established as a central driver of fibrosis in human liver injury. In the presence of chronic or repeated injury, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC) can occur, so there is interest in down-regulating aHSCs activity in order to tre...

Full description

Bibliographic Details
Main Authors: Xiaoying Zhou, Yanzheng Gu, Hongying Xiao, Ning Kang, Yonghua Xie, Guangbo Zhang, Yan Shi, Xiaoyu Hu, Eric Oldfield, Xueguang Zhang, Yonghui Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
activated human hepatic stellate cells
liver fibrosis
Vγ9Vδ2 T cells
lipophilic bisphosphonates
hepatocellular carcinoma
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01381/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01381/full

Similar Items