Effects of cell phenotype and seeding density on the chondrogenic capacity of human osteoarthritic chondrocytes in type I collagen scaffolds

Abstract Objective Matrix-associated autologous chondrocyte implantation (MACI) achieves good clinical efficacy in young patients with focal cartilage injury; however, phenotypic de-differentiation of chondrocytes cultured in monolayer and the treatment of older OA patients are still challenges in t...

Full description

Bibliographic Details
Main Authors: Chenxi Cao, Yujun Zhang, Yanqi Ye, Tiezheng Sun
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13018-020-01617-6