Microbiota-Sourced Purines Support Wound Healing and Mucous Barrier Function

Summary: The intestinal mucosa requires high levels of nucleotides for energy procurement, proliferation, and innate immunity. This need for nucleotide substrates substantially increases during injury, infection, and wound healing. In the present studies, we profile potential sources of purine nucle...

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Bibliographic Details
Main Authors: J. Scott Lee, Ruth X. Wang, Matthew S. Goldberg, Garrett P. Clifford, Daniel J. Kao, Sean P. Colgan
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220304119