Pharmacokinetic and Toxicodynamic Characterization of a Novel Doxorubicin Derivative

Pharmacokinetic and Toxicodynamic Characterization of a Novel Doxorubicin Derivative

Doxorubicin (Dox) is an effective anti-cancer medication with poor oral bioavailability and systemic toxicities. DoxQ was developed by conjugating Dox to the lymphatically absorbed antioxidant quercetin to improve Dox’s bioavailability and tolerability. The purpose of this study was to characterize...

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Bibliographic Details
Main Authors: Samaa Alrushaid, Casey L. Sayre, Jaime A. Yáñez, M. Laird Forrest, Sanjeewa N. Senadheera, Frank J. Burczynski, Raimar Löbenberg, Neal M. Davies
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Pharmaceutics
Subjects:
doxorubicin
quercetin
pharmacokinetics
bioavailability
lymphatics transport
toxicity
Online Access:https://www.mdpi.com/1999-4923/9/3/35

Internet

https://www.mdpi.com/1999-4923/9/3/35

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