Striatal inhibition of calpains prevents levodopa-induced neurochemical changes and abnormal involuntary movements in the hemiparkinsonian rat model

Striatal inhibition of calpains prevents levodopa-induced neurochemical changes and abnormal involuntary movements in the hemiparkinsonian rat model

Pharmacological dopamine replacement with l-3,4-dihydroxyphenylalanine (l-DOPA) remains the most effective approach to treat the motor symptoms of Parkinson's disease (PD). However, as the disease progresses, the therapeutic response to l-DOPA gradually becomes erratic and is associated with th...

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Bibliographic Details
Main Authors: Laure Chagniel, Christine Robitaille, Manon Lebel, Michel Cyr
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
6-Hydroxydopamine
Levodopa
Dyskinesia
Caudate-putamen
cdk5
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111003433

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http://www.sciencedirect.com/science/article/pii/S0969996111003433

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