A Role for BLM in Double-Strand Break Repair Pathway Choice: Prevention of CtIP/Mre11-Mediated Alternative Nonhomologous End-Joining

A Role for BLM in Double-Strand Break Repair Pathway Choice: Prevention of CtIP/Mre11-Mediated Alternative Nonhomologous End-Joining

The choice of the appropriate double-strand break (DSB) repair pathway is essential for the maintenance of genomic stability. Here, we show that the Bloom syndrome gene product, BLM, counteracts CtIP/MRE11-dependent long-range deletions (>200 bp) generated by alternative end-joining (A-EJ). BLM...

Full description

Bibliographic Details
Main Authors: Anastazja Grabarz, Josée Guirouilh-Barbat, Aurélia Barascu, Gaëlle Pennarun, Diane Genet, Emilie Rass, Susanne M. Germann, Pascale Bertrand, Ian D. Hickson, Bernard S. Lopez
Format: Article
Language:English
Published: Elsevier 2013-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713004750

Internet

http://www.sciencedirect.com/science/article/pii/S2211124713004750

Similar Items