N-terminal mutation of apoA-I and interaction with ABCA1 reveal mechanisms of nascent HDL biogenesis

N-terminal mutation of apoA-I and interaction with ABCA1 reveal mechanisms of nascent HDL biogenesis

ApoA-I and ABCA1 play important roles in nascent HDL (nHDL) biogenesis, the first step in the pathway of reverse cholesterol transport that protects against cardiovascular disease. On the basis of the crystal structure of a C-terminally truncated form of apoA-I[Δ(185-243)] determined in our laborato...

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Bibliographic Details
Main Authors: Minjing Liu, Xiaohu Mei, Haya Herscovitz, David Atkinson
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Journal of Lipid Research
Subjects:
adenosine 5′-triphosphate binding cassette transporter A1
apolipoproteins
atherosclerosis
cholesterol efflux
high density lipoprotein
lipids efflux
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752032664X

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http://www.sciencedirect.com/science/article/pii/S002222752032664X

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