Molecular interaction of TPPP with PrP antagonized the CytoPrP-induced disruption of microtubule structures and cytotoxicity.

Molecular interaction of TPPP with PrP antagonized the CytoPrP-induced disruption of microtubule structures and cytotoxicity.

BACKGROUND: Tubulin polymerization promoting protein/p25 (TPPP/p25), known as a microtubule-associated protein (MAP), is a brain-specific unstructured protein with a physiological function of stabilizing cellular microtubular ultrastructures. Whether TPPP involves in the normal functions of PrP or t...

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Main Authors: Rui-Min Zhou, Yuan-Yuan Jing, Yan Guo, Chen Gao, Bao-Yun Zhang, Cao Chen, Qi Shi, Chan Tian, Zhao-Yun Wang, Han-Shi Gong, Jun Han, Bian-Li Xu, Xiao-Ping Dong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3155546?pdf=render

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http://europepmc.org/articles/PMC3155546?pdf=render

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