Building the vertebrate codex using the gene breaking protein trap library

Building the vertebrate codex using the gene breaking protein trap library

One key bottleneck in understanding the human genome is the relative under-characterization of 90% of protein coding regions. We report a collection of 1200 transgenic zebrafish strains made with the gene-break transposon (GBT) protein trap to simultaneously report and reversibly knockdown the tagge...

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Bibliographic Details
Main Authors: Noriko Ichino, MaKayla R Serres, Rhianna M Urban, Mark D Urban, Anthony J Treichel, Kyle J Schaefbauer, Lauren E Greif, Gaurav K Varshney, Kimberly J Skuster, Melissa S McNulty, Camden L Daby, Ying Wang, Hsin-kai Liao, Suzan El-Rass, Yonghe Ding, Weibin Liu, Jennifer L Anderson, Mark D Wishman, Ankit Sabharwal, Lisa A Schimmenti, Sridhar Sivasubbu, Darius Balciunas, Matthias Hammerschmidt, Steven Arthur Farber, Xiao-Yan Wen, Xiaolei Xu, Maura McGrail, Jeffrey J Essner, Shawn M Burgess, Karl J Clark, Stephen C Ekker
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
protein trap
gene-break transposon
disease model
human genetic disorders
light sheet microscopy
gene reversion
Online Access:https://elifesciences.org/articles/54572

Internet

https://elifesciences.org/articles/54572

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