Interleukin-6 Trans-Signaling Pathway Promotes Immunosuppressive Myeloid-Derived Suppressor Cells via Suppression of Suppressor of Cytokine Signaling 3 in Breast Cancer

Interleukin-6 Trans-Signaling Pathway Promotes Immunosuppressive Myeloid-Derived Suppressor Cells via Suppression of Suppressor of Cytokine Signaling 3 in Breast Cancer

Interleukin-6 (IL-6) has been reported to stimulate myeloid-derived suppressor cells (MDSCs) in multiple cancers, but the molecular events involved in this process are not completely understood. We previously found that cancer-derived IL-6 induces T cell suppression of MDSCs in vitro via the activat...

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Bibliographic Details
Main Authors: Mengmeng Jiang, Jieying Chen, Wenwen Zhang, Rui Zhang, Yingnan Ye, Pengpeng Liu, Wenwen Yu, Feng Wei, Xiubao Ren, Jinpu Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
breast cancer
interleukin-6
myeloid-derived suppressor cells
suppressor of cytokine signaling 3
the JAK/STAT signaling pathway
trans-signaling pathway
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01840/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01840/full

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