Anti-human α-synuclein N-terminal peptide antibody protects against dopaminergic cell death and ameliorates behavioral deficits in an AAV-α-synuclein rat model of Parkinson's disease.

Anti-human α-synuclein N-terminal peptide antibody protects against dopaminergic cell death and ameliorates behavioral deficits in an AAV-α-synuclein rat model of Parkinson's disease.

The protein α-synuclein (α-Syn) has a central role in the pathogenesis of Parkinson's disease (PD) and immunotherapeutic approaches targeting this molecule have shown promising results. In this study, novel antibodies were generated against specific peptides from full length human α-Syn and eva...

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Bibliographic Details
Main Authors: Md Shahaduzzaman, Kevin Nash, Charles Hudson, Masroor Sharif, Bethany Grimmig, Xiaoyang Lin, Ge Bai, Hui Liu, Kenneth E Ugen, Chuanhai Cao, Paula C Bickford
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4319932?pdf=render

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http://europepmc.org/articles/PMC4319932?pdf=render

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