Somatostatin receptor 1 and 5 double knockout mice mimic neurochemical changes of Huntington's disease transgenic mice.

Somatostatin receptor 1 and 5 double knockout mice mimic neurochemical changes of Huntington's disease transgenic mice.

Selective degeneration of medium spiny neurons and preservation of medium sized aspiny interneurons in striatum has been implicated in excitotoxicity and pathophysiology of Huntington's disease (HD). However, the molecular mechanism for the selective sparing of medium sized aspiny neurons and v...

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Bibliographic Details
Main Authors: Padmesh S Rajput, Geetanjali Kharmate, Michael Norman, Shi-He Liu, Bhagavatula R Sastry, Charles F Brunicardi, Ujendra Kumar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3166321?pdf=render

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http://europepmc.org/articles/PMC3166321?pdf=render

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