HER2-Specific Targeted Toxin DARPin-LoPE: Immunogenicity and Antitumor Effect on Intraperitoneal Ovarian Cancer Xenograft Model

HER2-Specific Targeted Toxin DARPin-LoPE: Immunogenicity and Antitumor Effect on Intraperitoneal Ovarian Cancer Xenograft Model

High immunogenicity and systemic toxicity are the main obstacles limiting the clinical use of the therapeutic agents based on <i>Pseudomonas aeruginosa</i> exotoxin A. In this work, we studied the immunogenicity, general toxicity and antitumor effect of the targeted toxin DARPin-LoPE com...

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Bibliographic Details
Main Authors: Evgeniya A. Sokolova, Olga N. Shilova, Daria V. Kiseleva, Alexey A. Schulga, Irina V. Balalaeva, Sergey M. Deyev
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
targeted therapy
DARPin
<i>Pseudomonas</i> exotoxin A
immunogenicity
ovarian carcinoma
HER2
far-red fluorescent protein
Online Access:https://www.mdpi.com/1422-0067/20/10/2399

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https://www.mdpi.com/1422-0067/20/10/2399

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