Pteridines, IXC. Synthesis, Oxidations and Reactions of 6- and 7-Hydroxy-2-thiolumazines Selective Cytotoxicity of Carboxypeptidase-activated Methotrexate ex-Peptides
Various 6-(10, 11) and 7-hydroxy-2-thiolumazines (8,9) have been synthesized and oxidations of the thioamide function studied . H20 2 Oxidation of 7-hydroxy-2-thiolumazine (8) in basic medium leads to pteridine-4,7- dione-2-sulfinate (12), which eliminates S02 in anhydrous acids. Oxidative desulfuri...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
1989-02-01
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| Series: | Pteridines |
| Online Access: | https://doi.org/10.1515/pteridines.1989.1.1.57 |