Chordin-Like 1 Improves Osteogenesis of Bone Marrow Mesenchymal Stem Cells Through Enhancing BMP4-SMAD Pathway

Chordin-Like 1 Improves Osteogenesis of Bone Marrow Mesenchymal Stem Cells Through Enhancing BMP4-SMAD Pathway

Chordin-like 1 (CHRDL1) is a secreted glycoprotein with repeated cysteine-rich domains, which can bind to BMPs family ligands. Although it has been reported to play important roles in several systems, the exact roles of CHRDL1 on human bone mesenchymal stem cells (hBMSCs) osteogenesis remain to be e...

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Bibliographic Details
Main Authors: Tao Liu, Bo Li, Xin-Feng Zheng, Sheng-Dan Jiang, Ze-Zhu Zhou, Wen-Ning Xu, Huo-Liang Zheng, Chuan-Dong Wang, Xiao-Ling Zhang, Lei-Sheng Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Endocrinology
Subjects:
CHRDL1
hBMSCs
BMP-4
SMAD
RUNX2
osteogenic differentiation
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00360/full

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https://www.frontiersin.org/article/10.3389/fendo.2019.00360/full

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