Activities of Endochin-Like Quinolones Against in vitro Cultured Besnoitia besnoiti Tachyzoites

Activities of Endochin-Like Quinolones Against in vitro Cultured Besnoitia besnoiti Tachyzoites

Endochin-like quinolones (ELQs) potently inhibit the proliferation of Plasmodium, Toxoplasma, Neospora, and Babesia by targeting the cytochrome b Qo and Qi sites and interfering with oxidative phosphorylation and pyrimidine biosynthesis. The activities of 14 different ELQs were assessed against B. b...

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Bibliographic Details
Main Authors: Naja Eberhard, Vreni Balmer, Joachim Müller, Norbert Müller, Rolf Winter, Soviti Pou, Aaron Nilsen, Mike Riscoe, Samuel Francisco, Alexandre Leitao, J. Stone Doggett, Andrew Hemphill
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Veterinary Science
Subjects:
Besnoitia besnoiti
endochin-like quinolones
SAR
electron microscopy
mitochondrial inhibition
Online Access:https://www.frontiersin.org/article/10.3389/fvets.2020.00096/full

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https://www.frontiersin.org/article/10.3389/fvets.2020.00096/full

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