Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities

Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities

Multimorbidities of common diseases often have shared underlying predisposing factors. Here Fadason et al. study the pleiotropy of SNPs and their effects on target genes by integrating chromatin interaction and expression quantitative trait loci data to identify target genes shared between phenotype...

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Main Authors: Tayaza Fadason, William Schierding, Thomas Lumley, Justin M. O’Sullivan
Format: Article
Language:English
Published: Nature Publishing Group 2018-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07692-y
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spelling doaj-3010e481d22245b2943cd3ec1cf06e902021-05-11T10:27:44ZengNature Publishing GroupNature Communications2041-17232018-12-019111310.1038/s41467-018-07692-yChromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbiditiesTayaza Fadason0William Schierding1Thomas Lumley2Justin M. O’Sullivan3The Liggins Institute, The University of AucklandThe Liggins Institute, The University of AucklandThe Department of Biostatistics, The University of AucklandThe Liggins Institute, The University of AucklandMultimorbidities of common diseases often have shared underlying predisposing factors. Here Fadason et al. study the pleiotropy of SNPs and their effects on target genes by integrating chromatin interaction and expression quantitative trait loci data to identify target genes shared between phenotypes.https://doi.org/10.1038/s41467-018-07692-y
collection DOAJ
language English
format Article
sources DOAJ
author Tayaza Fadason
William Schierding
Thomas Lumley
Justin M. O’Sullivan
spellingShingle Tayaza Fadason
William Schierding
Thomas Lumley
Justin M. O’Sullivan
Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities
Nature Communications
author_facet Tayaza Fadason
William Schierding
Thomas Lumley
Justin M. O’Sullivan
author_sort Tayaza Fadason
title Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities
title_short Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities
title_full Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities
title_fullStr Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities
title_full_unstemmed Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities
title_sort chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-12-01
description Multimorbidities of common diseases often have shared underlying predisposing factors. Here Fadason et al. study the pleiotropy of SNPs and their effects on target genes by integrating chromatin interaction and expression quantitative trait loci data to identify target genes shared between phenotypes.
url https://doi.org/10.1038/s41467-018-07692-y
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AT williamschierding chromatininteractionsandexpressionquantitativetraitlocirevealgeneticdriversofmultimorbidities
AT thomaslumley chromatininteractionsandexpressionquantitativetraitlocirevealgeneticdriversofmultimorbidities
AT justinmosullivan chromatininteractionsandexpressionquantitativetraitlocirevealgeneticdriversofmultimorbidities
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