Metabolic Syndrome and Salt-Sensitive Hypertension in Polygenic Obese TALLYHO/JngJ Mice: Role of Na/K-ATPase Signaling

Metabolic Syndrome and Salt-Sensitive Hypertension in Polygenic Obese TALLYHO/JngJ Mice: Role of Na/K-ATPase Signaling

We have demonstrated that Na/K-ATPase acts as a receptor for reactive oxygen species (ROS), regulating renal Na<sup>+</sup> handling and blood pressure. TALLYHO/JngJ (TH) mice are believed to mimic the state of obesity in humans with a polygenic background of type 2 diabetes. This presen...

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Bibliographic Details
Main Authors: Yanling Yan, Jiayan Wang, Muhammad A. Chaudhry, Ying Nie, Shuyan Sun, Jazmin Carmon, Preeya T. Shah, Fang Bai, Rebecca Pratt, Cameron Brickman, Komal Sodhi, Jung Han Kim, Sandrine Pierre, Deepak Malhotra, Gary O. Rankin, Zi-jian Xie, Joseph I. Shapiro, Jiang Liu
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
Na/K-ATPase
salt-sensitive hypertension
obesity
metabolic syndrome
pressure-natriuresis curve
reactive oxygen species
Online Access:https://www.mdpi.com/1422-0067/20/14/3495

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https://www.mdpi.com/1422-0067/20/14/3495

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