Pan-caspase inhibitor F573 mitigates liver ischemia reperfusion injury in a murine model.

Pan-caspase inhibitor F573 mitigates liver ischemia reperfusion injury in a murine model.

BACKGROUND:Liver ischemia reperfusion injury (IRI) remains a challenge in liver transplantation. A number of compounds have previously demonstrated efficacy in mitigating IRI. Herein, we applied three specific additive strategies to a mouse IRI screening model to determine their relative potencies i...

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Bibliographic Details
Main Authors: Mariusz Bral, Rena Pawlick, Braulio Marfil-Garza, Nidheesh Dadheech, Joshua Hefler, Aducio Thiesen, A M James Shapiro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0224567

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https://doi.org/10.1371/journal.pone.0224567

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