Deactivation of ATP-Binding Cassette Transporters ABCB1 and ABCC1 Does Not Influence Post-ischemic Neurological Deficits, Secondary Neurodegeneration and Neurogenesis, but Induces Subtle Microglial Morphological Changes

Deactivation of ATP-Binding Cassette Transporters ABCB1 and ABCC1 Does Not Influence Post-ischemic Neurological Deficits, Secondary Neurodegeneration and Neurogenesis, but Induces Subtle Microglial Morphological Changes

ATP-binding cassette (ABC) transporters prevent the access of pharmacological compounds to the ischemic brain, thereby impeding the efficacy of stroke therapies. ABC transporters can be deactivated by selective inhibitors, which potently increase the brain accumulation of drugs. Concerns have been r...

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Bibliographic Details
Main Authors: Daniel Manrique-Castano, Maryam Sardari, Tayana Silva de Carvalho, Thorsten R. Doeppner, Aurel Popa-Wagner, Christoph Kleinschnitz, Andrew Chan, Dirk M. Hermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
focal cerebral ischemia
microglial morphology
mouse
multidrug resistance transporter
neurodegeneration
neurogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00412/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00412/full

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