Reciprocal actions of constrictor prostanoids and superoxide in chronic hypoxia-induced pulmonary hypertension: roles of EETs

Epoxyeicosatrienoic acids (EETs) are synthesized from arachidonic acid by CYP/epoxygenase and metabolized by soluble epoxide hydrolase (sEH). Roles of EETs in hypoxia-induced pulmonary hypertension (HPH) remain elusive. The present study aimed to investigate the underlying mechanisms, by which EETs...

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Bibliographic Details
Main Authors: Sharath Kandhi, Norah Alruwaili, Michael S Wolin, Dong Sun, An Huang
Format: Article
Language:English
Published: SAGE Publishing 2019-12-01
Series:Pulmonary Circulation
Online Access:https://doi.org/10.1177/2045894019895947