Association of UBQLN1 mutation with Brown–Vialetto–Van Laere syndrome but not typical ALS

Association of UBQLN1 mutation with Brown–Vialetto–Van Laere syndrome but not typical ALS

Genetic variants in UBQLN1 gene have been linked to neurodegeneration and mutations in UBQLN2 have recently been identified as a rare cause of amyotrophic lateral sclerosis (ALS). Objective: To test if genetic variants in UBQLN1 are involved in ALS. Methods: 102 and 94 unrelated patients with famili...

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Bibliographic Details
Main Authors: Paloma González-Pérez, Yubing Lu, Ru-Ju Chian, Peter C. Sapp, Rudolph E. Tanzi, Lars Bertram, Diane McKenna-Yasek, Fen-Biao Gao, Robert H. Brown, Jr.
Format: Article
Language:English
Published: Elsevier 2012-12-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
Drosophila motor neuron disease
TDP-43
Ubiquilins
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112002331

Internet

http://www.sciencedirect.com/science/article/pii/S0969996112002331

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