Nucleophosmin Protein Dephosphorylation by DUSP3 Is a Fine-Tuning Regulator of p53 Signaling to Maintain Genomic Stability

Nucleophosmin Protein Dephosphorylation by DUSP3 Is a Fine-Tuning Regulator of p53 Signaling to Maintain Genomic Stability

The dual-specificity phosphatase 3 (DUSP3), an atypical protein tyrosine phosphatase (PTP), regulates cell cycle checkpoints and DNA repair pathways under conditions of genotoxic stress. DUSP3 interacts with the nucleophosmin protein (NPM) in the cell nucleus after UV-radiation, implying a potential...

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Bibliographic Details
Main Authors: Lilian C. Russo, Pault Y. M. Ferruzo, Fabio L. Forti
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
nucleophosmin (NPM)
DUSP3/VHR
p53
genomic stability
tyrosine dephosphorylation
NPM translocation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.624933/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.624933/full

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