Paralog dependency indirectly affects the robustness of human cells

Abstract The protective redundancy of paralogous genes partly relies on the fact that they carry their functions independently. However, a significant fraction of paralogous proteins may form functionally dependent pairs, for instance, through heteromerization. As a consequence, one could expect the...

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Bibliographic Details
Main Authors: Rohan Dandage, Christian R Landry
Format: Article
Language:English
Published: Wiley 2019-09-01
Series:Molecular Systems Biology
Subjects:
Online Access:https://doi.org/10.15252/msb.20198871