RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2

RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2

RALYL is a liver progenitor cell-specific gene but its role in hepatocellular carcinoma (HCC) remains unknown. Here, the authors demonstrate that RALYL regulates HCC stemness through upregulation of TGF-β2 mRNA stability by decreasing N6-methyladenosine modification.

Bibliographic Details
Main Authors: Xia Wang, Jin Wang, Yu-Man Tsui, Chaoran Shi, Ying Wang, Xin Zhang, Qian Yan, Miao Chen, Chen Jiang, Yun-Fei Yuan, Chun-Ming Wong, Ming Liu, Zeng-yu Feng, Honglin Chen, Irene Oi Lin Ng, Lingxi Jiang, Xin-Yuan Guan
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21828-7

Internet

https://doi.org/10.1038/s41467-021-21828-7

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