Annexin A5 as an immune checkpoint inhibitor and tumor-homing molecule for cancer treatment
AnnexinV has been shown to bind phosphatidylserine expressed by chemotherapy-induced apoptotic cells increasing their immunogeneicity. Here, the authors demonstrate in a preclinical tumor model that fusing tumor-antigen peptide to Annexin V enhances its efficacy when administered after chemotherapy...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-02-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-14821-z |