VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses.

PPARs (α,γ,δ) are a family of ligand-activated transcription factors that regulate energy balance, including lipid metabolism. Despite these critical functions, the integration between specific pathways of lipid metabolism and distinct PPAR responses remains obscure. Previous work has revealed that...

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Bibliographic Details
Main Authors: Jonathan D Brown, Eric Oligino, Daniel J Rader, Alan Saghatelian, Jorge Plutzky
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3130023?pdf=render